Dotoxin Res. 2002, 8, 403?17. Conneely, O.M. Antiinflammatory activities of lactoferrin. J. Am. Coll. Nutr. 2001, 20, 389S?95S. Baveye, S.; Elass, E.; Mazurier, J.; Spik, G.; Legrand, D. Lactoferrin: A multifunctional glycoprotein involved within the modulation in the inflammatory course of action. Clin. Chem. Lab. Med. 1999, 37, 281?86.two. 3. four.five. six.Int. J. Mol. Sci. 2014, 15 7. eight. 9. ten. 11. 12. 13.14.15.16.17. 18.19.20.21. 22.Baynes, R.D.; Bezwoda, W.R. Lactoferrin as well as the inflammatory response. Adv. Exp. Med. Biol. 1994, 357, 133?41. Kruzel, M.L.; Zimecki, M. Lactoferrin and immunologic dissonance: Clinical implications. Arch. Immunol. Ther. Exp. 2002, 50, 399?ten. Haber, F.; Weiss, J. On the catalysis of hydroperoxide. Naturwissenschaften 1932, 20, 948?50. Gutteridge, J.M. Hydroxyl radicals, iron, oxidative pressure, and neurodegeneration. Ann. N. Y. Acad. Sci. 1994, 738, 201?13. Pourzand, C.; Tyrrell, R.M. Apoptosis, the role of oxidative anxiety and also the instance of solar UV radiation. Photochem. Photobiol. 1999, 70, 380?90. Genestra, M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal. 2007, 19, 1807?819. Cheng, K.C.; Cahill, D.S.; Kasai, H.; Nishimura, S.; Loeb, L.A. 8-Hydroxyguanine, an abundant kind of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 1992, 267, 166?72. Valavanidis, A.; Vlachogianni, T.; Fiotakis, C. 8-Hydroxy-2′-deoxyguanosine (8-OHdG): A important biomarker of oxidative tension and carcinogenesis. J. Environ. Sci. Well being C Environ. Carcinog. Ecotoxicol. Rev. 2009, 27, 120?39. Tsuda, H.; Kozu, T.; Iinuma, G.; Ohashi, Y.; Saito, Y.; Saito, D.; Akasu, T.; Alexander, D.B.; Futakuchi, M.; Fukamachi, K.; et al. Cancer prevention by bovine lactoferrin: From animal studies to human trial. Biometals 2010, 23, 399?09. Kozu, T.; Iinuma, G.; Ohashi, Y.; Saito, Y.; Akasu, T.; Saito, D.; Alexander, D.B.; Iigo, M.; Kakizoe, T.; Tsuda, H. Impact of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps within a randomized, placebo-controlled clinical trial. Cancer Prev. Res. 2009, two, 975?83. Rodrigues, L.; Teixeira, J.; Schmitt, F.; Paulsson, M.; M sson, H.L. Lactoferrin and cancer disease prevention. Crit. Rev. Meals Sci. Nutr. 2009, 2, 975?83. Wei, H.; Cai, Q.; Rahn, R.; Zhang, X. Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-hydroxy-deoxyguanosine in DNA. Totally free Radic. Biol. Med. 1997, 23, 148?54. Wakabayashi, H.; Matsumoto, H.; Hashimoto, K.; Teraguchi, S.; Takase, M.; Hayasawa, H. Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives.2,2′-Dipyridyl disulfide Chemical name Biosci.2089377-51-3 structure Biotechnol.PMID:24238415 Biochem. 1999, 63, 955?57. Bennett, R.M.; Davis, J. Lactoferrin interacts with deoxyribonucleic acid: A preferential reactivity with double-stranded DNA and dissociation of DNA-anti-DNA complexes. J. Lab. Clin. Med. 1982, 99, 127?38. He, J.; Furmanski, P. Sequence specificity and transcriptional activation inside the binding of lactoferrin to DNA. Nature 1995, 373, 721?24. Ivanov, A.A.; Ulanova, A.M.; Stavrakova, N.M.; Deshevo, IuB.; Nasonova, T.A.; Koterov, A.N.; Gutsenko, K.K.; Mal’tsev, V.N. Antiradiation effects of lactoferrin. Radiats. Biol. Radioecol. 2009, 49, 456?61. (in Russian).Int. J. Mol. Sci. 2014,23. Akiyama, Y.; Oshima, K.; Shin, K.; Wakabayashi, H.; Abe, F.; Nadano, D.; Matsuda, T. Intracellular retention and subsequent release of bovine milk lactoferrin taken up by human enterocyte-like.