For C11H17N3O3: 239.27. Found: 239.eight (M+).3-(2,5-Dimethylfuran-3-yl)-1H-pyrazol-5(4H)-one (17)Purified by recrystallisation applying ethanol (white solid), m.p: 204.0 to 205.0 , 1H NMR (400 MHz, d6-DMSO) H: 5.67 (s, 1H, proton at C-4), 7.07 (bs, 1H, proton of thiophenyl ring), 7.32 (bs, 1H, proton of thiophenyl ring), 7.42 (bs, 1H, proton of thiophenyl ring), 9.67 (bs, 1H, -NH), 12.05 (bs, 1H, -OH). MS calculated for C7H6N2OS: 166.20. Found: 167.0 (M + 1).3-(5-Oxo-4,5-dihydro-1H-pyrazol-3-yl)benzonitrile (14)Purified by recrystallisation making use of ethanol (white strong), 1 H NMR (400 MHz, d6-DMSO) H: 2.21 (s, 3H, methyl proton of furan ring), 2.32 (s, 3H, methyl proton of furan ring), 5.51 (s, 1H, proton at C-4) six.27 (s, 1H, proton of furan ring), 9.60 (bs, 1H, -NH proton), 11.62 (bs, 1H, -OH proton). MS calculated for C9H10N2O2: 178.18. Found: 179. 0 (M + 1).Benzyl 3-oxo-2,3,3a,4,six,7-hexahydropyrazolo[4,3-c]pyridine5-carboxylate (18)Purified by recrystallisation employing ethanol (white strong). 1H NMR (400 MHz, d6-DMSO) H: six.02 (s, 1H, proton at C4), 7.59 (t, J = ten.4 Hz, 1H, aryl proton), 7.73 (d, J = ten.four Hz, 1H, aryl proton), 7.99 (d, J = 10.4, 1H, aryl proton), eight.12 (s, 1H, aryl proton), 10.00 (bs, 1H, -NH proton), 12.02 (bs, 1H, -OH proton). MS calculated for C10H7N3O: 185.18. Found: 184.0 (M-1).Ethyl 3-oxo-2,3,3a,four,six,7-hexahydropyrazolo[4,3-c]pyridine-5caboxylate (15)Purified by recrystallisation employing ethanol (white solid), m.p: 225.4 to 226.1 , 1H NMR (400 MHz, d6-DMSO) H: two.50 to 2.56 (m, 2H, protons of ring B), three.61 (s, 2H, protons of ring B), four.23 (d, J = 10.80 Hz, 2H, protons of ring B), 5.ten (s, 2H, protons of methylene of Cbz group), 7.38 to 7.30 (m, 5H, aryl protons of Cbz), 9.88 (bs, 1H, -NH proton), 11.16 (bs, 1H, -OH proton); 13C NMR (one hundred MHz, d6-DMSO): 41.27, 42.77, 66.39 (carbons of ring B), 86.72 (C-4), 127.69, 127.01, 128.46 (aryl carbons), 136.90 (C-3), 157.72 (C-5). MS calculated for C14H15N3O3: 273.28. Discovered: 273.eight (M+).5-Tert-butyl-4,five,6,7-tetrahydro-2H-indazol-3(3aH)-one (19)Purified by recrystallisation using ethanol (white strong), m.p: 212.5 to 213. 8 , 1H NMR (400 MHz, d6DMSO) H: 1.90 (t, J = 7.08 Hz, 3H, methyl of ethyl group), 2.50 (m, 2H, protons of ring B), three.56 (t, J = 5.7 Hz, 2H, protons of ring B), 4.04 (q, J = 7.08 Hz, 2H, methylene of ethyl group), 4.18 (s, 2H, protons of ring B), 9.80 (bs, 1H, -NH proton), 11.30 (bs, 1H, -OH proton); 13C NMR (one hundred MHz, d6-DMSO): 14.62 (methyl carbon of ethyl group), 21.62 (carbon of ring B), 21.92 (methylene carbon of ethyl group), 60.89, 96.06 (C-4 of pyrazole ring), 138.12, 155.08 (C-3 of pyrazole ring), 156.33 (C-5 of pyrazole ring). MS calculated for C9H13N3O3: 211.BuyFmoc-β-azido-Ala-OH 21.Price of 5-Cyano-2-Furancarboxylic acid Found: 212.PMID:24818938 0 (M + 1).Tert-butyl 3-oxo-2,three,3a,four,6,7-hexahydropyrazolo[4,3-c] pyridine-5-carboxylate (16)Purified by recrystallisation using ethanol (white solid), m.p: 243.5 to 244.eight , 1H NMR (400 MHz, d6-DMSO) H: 0.89 (s, 9H, protons of three methyl groups), 1.18 to 1.25 (m, 2H, protons of ring B), 1.85 to 1.92 (m, 2H, protons of ring B), 2.39 to two.29 (m, 2H, protons of ring B), two.55 (m, 1H, proton of ring B); 13C NMR (100 MHz, d6DMSO): 20.73 (carbons of methyl groups of tertiary group), 22.54, 24.48, 27.81, 27.85, 32.70, 45.50 (quaternary carbon of tertiary group), 99.42 (C-4 of pyrazole ring), 140.46 (C-3 of pyrazole ring), 158.88 (C-5 of pyrazole ring). MS calculated for C11H18N2O: 194.21. Found: 194.8 (M+).3-(Biphenyl-4-yl)-1-(4-fluorophenyl)-1H-pyrazol-5(4H)-one (20)Purified by recrystallisation.