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Metab 2007, 9:609?16. 47. Russo GT, Horvath KV, Di Benedetto A, Giandalia A, Cucinotta D, Asztalos B: Influence of menopause and cholesteryl ester transfer protein (CETP) TaqIB polymorphism on lipid profile and HDL subpopulations distribution in females with and without type two diabetes. Atherosclerosis 2010, 210:294?01. 48. Hyv inen M, Tuomilehto J, Laatikainen T, S erberg S, Eliasson M, Nilsson P, Qiao Q: The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the gender. Cardiovasc Diabetol 2009, eight:17. 49. Liu Z, Ho SC: The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. Maturitas 2011, 70:176?81. 50. G l CS, Bozkurt L, Lueck J, El-Samahi M, Gr ser P, Clodi M, Luger A, Kautzky-Willer A: Sex-specific differences in long-term glycemic control and cardiometabolic parameters in individuals with type 1 diabetes treated at a tertiary care centre: gender elements in type 1 diabetes. Wien Klin Wochenschr 2012, 124:742?49. 51. Lin W-Y, Yang W-S, Lee L-T, Chen C-Y, Liu C-S, Lin C-C, Huang K-C: Insulin resistance, obesity, and metabolic syndrome amongst non-diabetic pre- and post-menopausal ladies in North Taiwan. Int J Obes 2006, 30:912?17. 52. Saltiki K, Cimponeriu A, Lili K, Peppa M, Anastasiou E, Alevizaki M: Severity of coronary artery illness in postmenopausal diabetic ladies. Hormones 2008, 7(2):148?55.doi:ten.1186/1475-2840-12-61 Cite this article as: Mascarenhas-Melo et al.: Diabetes abrogates sex differences and aggravates cardiometabolic danger in postmenopausal females. Cardiovascular Diabetology 2013 12:61.Submit your next manuscript to BioMed Central and take full advantage of:?Practical on the net submission ?Thorough peer overview ?No space constraints or colour figure charges ?Quick publication on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Research which is freely available for redistributionSubmit your manuscript at biomedcentral/submit
NIH Public AccessAuthor ManuscriptBiochemistry.Price of 1003309-09-8 Author manuscript; obtainable in PMC 2014 April 16.Published in final edited form as: Biochemistry. 2013 April 16; 52(15): 2536?544. doi:10.1021/bi301562n.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDNA Translocation by Human Uracil DNA Glycosylase: The Case of ssDNA and Clustered UracilsJoseph D.Fmoc-His(3-Me)-OH Order Schonhoft and James T.PMID:24065671 Stivers* Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-AbstractHuman uracil DNA glycosylase (hUNG) plays a central part in DNA repair and programmed mutagenesis of Ig genes, requiring it to act on sparsely or densely spaced uracil bases located within a assortment of contexts, such as U/A and U/G base pairs, and potentially uracils within single stranded DNA. An fascinating query is whether or not the facilitated search mode of hUNG, which incorporates both DNA sliding and hopping, modifications in these different contexts. Here we locate that hUNG makes use of an enhanced local search mode when it acts on uracils in ssDNA, as well as, in a context exactly where uracils are densely clustered in duplex DNA. Within the context of ssDNA hUNG performs an enhanced neighborhood search by sliding using a larger mean sliding length as in comparison with dsDNA. In the context of duplex DNA, insertion of high-affinity abasic item web-sites involving two uracil lesions serves to considerably extend the ap.