Receptor; VEGFR: Vascular endothelial growth aspect receptor; TKI: Tyrosine kinase inhibitor; RT: Radio-therapy. Competing interests The authors declare that they’ve no competing interests. Authors’ contributions SS developed, carried out the experiments and also ready the draft of the manuscript. SR and AK helped in cell culture, preparation of slides for microscopy, as well as correcting the manuscript. MM approved the experimental style, assisting the experiments and help in preparing the final draft of the manuscript. All authors study and authorized the final manuscript. Acknowledgements The present investigation was supported in component by Department of Biotechnology (DBT), INDIA grant BT/PR13996/Med/30/309/2010 (to MM), and Department of Science and Technologies (DST), INDIA grant SR/SO/BB-58/2008 (to MM). SS was the recipient of Senior Research Scholarship from CSIR, INDIA. SR could be the recipient of Senior Research Scholarship from CSIR, INDIA. Received: five April 2013 Accepted: 8 October 2013 Published: 20 October 2013 References 1. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, et al: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on regional recurrence and 15-year survival: an overview on the randomised trials. Lancet 2005, 366:2087?106. two. Gyenes G: Radiation-induced ischemic heart illness in breast cancer?a review. Acta oncologica 1998, 37:241?46. three. Arbetter KR, Prakash UB, Tazelaar HD, Douglas WW: Radiation-induced pneumonitis inside the “nonirradiated” lung. Mayo Clin Proc 1999, 74:27?6. four. Zhang Z, Shao S, Meistrich ML: The radiation-induced block in spermatogonial differentiation is as a result of damage towards the somatic environment, not the germ cells. J Cell Physiol 2007, 211:149?58. 5. Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR, Li JJ: NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance. Radiat Res 2009, 171:9?1. 6. Li T, Zeng ZC, Wang L, Qiu SJ, Zhou JW, Zhi XT, Yu HH, Tang ZY: Radiation enhances long-term metastasis possible of residual hepatocellular carcinoma in nude mice by means of TMPRSS4-induced epithelialmesenchymal transition. Cancer Gene Ther 2011, 18:617?26. 7. Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H: Light, like ultraviolet.870991-70-1 Chemical name J Autoimmun 2010, 34:J247 257. 8. Lee E, Koo J, Berger T: UVB phototherapy and skin cancer risk: a review of your literature. Int J Dermatol 2005, 44:355?60. 9. Fabris C, Valduga G, Miotto G, Borsetto L, Jori G, Garbisa S, Reddi E: Photosensitization with zinc (II) phthalocyanine as a switch inside the decision in between apoptosis and necrosis.BuyOxetane-3-carboxylic acid Cancer research 2001, 61:7495?500.PMID:28440459 ten. Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, Brash DE: Melanin acts as a potent UVB photosensitizer to bring about an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 2004, 101:15076?5081. 11. Mitchell DL, Nairn RS: The biology of the (six?) photoproduct. Photochem Photobiol 1989, 49:805?19. 12. Chadwick CA, Potten CS, Nikaido O, Matsunaga T, Proby C, Young AR: The detection of cyclobutane thymine dimers, (6?) photolesions plus the Dewar photoisomers in sections of UV-irradiated human skin making use of precise antibodies, plus the demonstration of depth penetration effects. J Photochem Photobiol B Biol 1995, 28:163?70.Breast cancer cells had been treated with ZD6474 and/or UV-B and incubated in incomplete medium for 48 h. The conditioned medium (CM) was collected a.